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KMID : 0378019900330090030
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New Medical Journal
1990 Volume.33 No. 9 p.30 ~ p.38
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The Histopathological Study of the Capsules around Miniature Breast Implants in rats
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Abstract
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The most common complication of augmentation mammaplasty is the formation of a constrictive fibrous capsule around the implant. As for the cause of capsular contracture, contractibility of fibroblast or reorganization of collagen fiber is suggested.
In order to investigate the histopathological structure of the capsule, we inserted a miniature silicone breast implant below the panniculus carnosus of the rat. After 1 week, 2weeks, 1 month and 3 months, capsular tissue around the implant was examined with light microscope, transmission and scanning electron microscope. For the type of the collagen fiber, immunocytochemical study was performed. The results were as follows ;
1. In the early stage, numerous fibroblasts were found. But with the lapse of time, the number of the fibroblast decreased and the collagen fiber increased in amount and arranged in a parallel direction.
2. One week after insertion, most of collagen fibers were type Ill , but later, they were displaced by type I collagen.
3. A few classic myofifbroblasts appeared in the early stage, but they disappeared later, so they would not play an important role in capsular contracture.
From these results, it is suggested that structural reorganization of collagen fibers is the major cause of the capsular contracture.
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